The impact of environmental risk factors on HIV-associated cognitive decline in children
Identifieur interne : 001E79 ( Main/Exploration ); précédent : 001E78; suivant : 001E80The impact of environmental risk factors on HIV-associated cognitive decline in children
Auteurs : C. J. Hochhauser [États-Unis] ; S. Gaur [États-Unis] ; R. Marone [États-Unis] ; M. Lewis [États-Unis]Source :
- AIDS Care : (Print) [ 0954-0121 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Santé publique, Santé mentale, Enfant.
English descriptors
- KwdEn :
Abstract
Both the human immunodeficiency virus (HIV) and environmental stress have been independently associated with decreased cognitive functioning in children. Given that they are also known to have a strong relationship with each other, the present study sought to test the hypothesis that children in conditions of high environmental risk would be at greater risk for the cognitive complications related to immunosuppression. A retrospective review was conducted to examine the records of 141 children treated at a large pediatric AIDS clinic from 1993 to 2000. CD4 + lymphocyte levels were recorded from laboratory results and IQ scores were recorded from routine psychological evaluations. Key indicators of environmental risk were collected and combined into one measure of overall environmental risk. Pearson product moment correlations were conducted to examine the relationship between environmental risk, age-adjusted CD4 and IQ. Results indicated a significant correlation between CD4 and IQ, with higher levels of immunocompetence predicting higher IQ scores. When subjects were dichotomized based on their environmental risk score, there was no relationship between CD4 count and IQ in the low environmental risk group. In contrast, CD4 was positively associated with IQ in the high environmental risk group. It is proposed that this may be due to gpl20 levels in immunocompromised children being particularly toxic to the hippocampus and cortex under conditions of high stress but not so under conditions of low stress.
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J." last="Hochhauser">C. J. Hochhauser</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Medicine and Dentistry of NJ, Institute for the Study of Child Development</s1><s2>New Brunswick</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Brunswick</wicri:noRegion></affiliation></author><author><name sortKey="Gaur, S" sort="Gaur, S" uniqKey="Gaur S" first="S." last="Gaur">S. Gaur</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Medicine and Dentistry of NJ, Pediatric Allergy, Immunology and Infectious Disease</s1><s2>New Brunswick</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Brunswick</wicri:noRegion></affiliation></author><author><name sortKey="Marone, R" sort="Marone, R" uniqKey="Marone R" first="R." last="Marone">R. Marone</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Medicine and Dentistry of NJ, Pediatric Allergy, Immunology and Infectious Disease</s1><s2>New Brunswick</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Brunswick</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, M" sort="Lewis, M" uniqKey="Lewis M" first="M." last="Lewis">M. Lewis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Medicine and Dentistry of NJ, Institute for the Study of Child Development</s1><s2>New Brunswick</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New Brunswick</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">AIDS Care : (Print)</title><title level="j" type="abbreviated">AIDS Care : (Print)</title><idno type="ISSN">0954-0121</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">AIDS Care : (Print)</title><title level="j" type="abbreviated">AIDS Care : (Print)</title><idno type="ISSN">0954-0121</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Adolescent</term><term>Child</term><term>Cognitive disorder</term><term>Environmental factor</term><term>Health and environment</term><term>Human immunodeficiency virus</term><term>Intellectual deterioration</term><term>Mental health</term><term>Preschool age</term><term>Public health</term><term>Retrospective</term><term>Risk factor</term><term>School age</term><term>Social environment</term><term>Stress</term><term>United States</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Facteur milieu</term><term>Santé et environnement</term><term>Facteur risque</term><term>SIDA</term><term>Virus immunodéficience humaine</term><term>Détérioration intellectuelle</term><term>Trouble cognitif</term><term>Stress</term><term>Rétrospective</term><term>Santé publique</term><term>Santé mentale</term><term>Environnement social</term><term>Etats-Unis</term><term>Enfant</term><term>Age préscolaire</term><term>Age scolaire</term><term>Adolescent</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Santé publique</term><term>Santé mentale</term><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Both the human immunodeficiency virus (HIV) and environmental stress have been independently associated with decreased cognitive functioning in children. Given that they are also known to have a strong relationship with each other, the present study sought to test the hypothesis that children in conditions of high environmental risk would be at greater risk for the cognitive complications related to immunosuppression. A retrospective review was conducted to examine the records of 141 children treated at a large pediatric AIDS clinic from 1993 to 2000. CD4 + lymphocyte levels were recorded from laboratory results and IQ scores were recorded from routine psychological evaluations. Key indicators of environmental risk were collected and combined into one measure of overall environmental risk. Pearson product moment correlations were conducted to examine the relationship between environmental risk, age-adjusted CD4 and IQ. Results indicated a significant correlation between CD4 and IQ, with higher levels of immunocompetence predicting higher IQ scores. When subjects were dichotomized based on their environmental risk score, there was no relationship between CD4 count and IQ in the low environmental risk group. In contrast, CD4 was positively associated with IQ in the high environmental risk group. It is proposed that this may be due to gpl20 levels in immunocompromised children being particularly toxic to the hippocampus and cortex under conditions of high stress but not so under conditions of low stress.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Hochhauser, C J" sort="Hochhauser, C J" uniqKey="Hochhauser C" first="C. J." last="Hochhauser">C. J. Hochhauser</name></noRegion><name sortKey="Gaur, S" sort="Gaur, S" uniqKey="Gaur S" first="S." last="Gaur">S. Gaur</name><name sortKey="Lewis, M" sort="Lewis, M" uniqKey="Lewis M" first="M." last="Lewis">M. Lewis</name><name sortKey="Marone, R" sort="Marone, R" uniqKey="Marone R" first="R." last="Marone">R. Marone</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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